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KMID : 0359719920100030324
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Journal of the Korean Neurological Association
1992 Volume.10 No. 3 p.324 ~ p.330
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Tc-99m HMPAO SPECT in Olivopontocerebellar Atrophy
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이상수
윤병우/노재규/김상은/이명철
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Abstract
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We studied local cerebral blood flow with tc-99m HMPAO SPECT in 15 patients with olivopontocerebellar atrophy (OPCA) and age-matched control subjects without neurological desease. The diagnosis of OPCA was based upon the history and physical
findings
and upon the exclusion of other causes of cerebellar ataxia by means of laboratory investigations. Computed tomographic scans or MRI revealed some degree of atrophy of the cerebellum in most patients with OPCA, and many also had atrophy of the
brain
stem SPECT studies in these patients revealed decreased cerebral blood flow in the cerebellum in comparison with the normal control subjects (p<0.001). Two patients with minimal atrophy or nostructural changes in the cerebellum also showed
decreased
perfusion. Tc-99m HMPAO SPECT may be useful as a diagnostients with OPCA. Some instances suggest that Tc-99m HMPAO SPECT may show abnormal finding earlier than other neuroimaging methods.
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